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刘春雨

 

基本信息

202412270904573256.Jpeg

姓名：

刘春雨

职称：

副研究员

导师类型：

硕士研究生导师

专业：

遗传学

研究方向：

男性不育的遗传致病机理和临床干预

邮箱地址：

liuchunyu@shsmu.edu.cn

个人简介


长期致力于男性不育相关疾病和精子发生障碍的基础和临床研究。前期，利用全外显子测序与比较基因组杂交相结合的遗传分析手段，结合小鼠、树鼩以及食蟹猴等多个模式生物，解析了多个弱畸精子症致病基因及其致病机理。同时，基于大量胚胎数的统计分析，揭示了多个弱畸精子症致病基因对应的辅助生殖结局。相关研究为弱畸精子症患者临床治疗过程中遗传咨询、个性化治疗方案的建立提供了有效的指导。以第一/通讯作者（含共同）于American Journal of Human Genetics（AJHG）、SCIENCE CHINA Life Sciences（Sci China Life Sci）、Journal of Medical Genetics (JMG)、Journal of Genetics and Genomics（JGG）等领域内知名学术期刊发表多篇研究论文。任中国遗传学会青年委员会委员、中国康复医学会生殖健康专业委员会委员。曾获全国妇幼健康科学技术奖一等奖、“谈家桢博士后学者奖”等奖励。主持多项国家自然科学基金，并入选2023 年东方英才计划青年项目（原上海青年拔尖人才）。


主要科研项目：

1． 国家自然科学基金委员会, 面上项目, 32370654, 灵长类特异基因缺陷导致弱畸精子症的致病机理研究, 项目负责人。

2.  国家自然科学基金委员会, 青年科学基金项目, 32100480, CFAP65基因缺陷导致弱畸精子症和ICSI失败的分子机制, 项目负责人。

3. 上海市委组织部, 东方英才计划青年项目（原上海青年拔尖人才）, 弱畸精子症的遗传致病机理及临床干预, 项目负责人。

4. 中国博士后科学基金会, 中国博士后科学基金第2批特别资助（站前）, 2020TQ0072, 弱畸精子症遗传分析及辅助生殖结局差异探究, 项目负责人。


代表性论文：

1.Zhou Y*, Tu C*, Coutton C*, Tang J*, Tian S*, Tang S, Martinez G, Zhou D, Tebbakh C, Wang J, Zouari R, Zhou X, Ben Mustapha SF, Wang X, Wu B, Geng X, Liu S, Jin L, Shi H, Tan YQ, Ray PF, Wang L#, Yang X#, Zhang F#, Liu C#. Homozygous deleterious variants in MYCBPAP induce asthenoteratozoospermia involving abnormal acrosome biogenesis, manchette structure and sperm tail assembly in humans and mice. Science China Life Sciences. 2024, doi: 10.1007/s11427-024-2757-7.

2.Zhou D*, Wu H*, Wang L*, Wang X*, Tang S*, Zhou Y, Wang J, Wu B, Tang J, Zhou X, Tian S, Liu S, Lv M, He X, Jin L, Shi H, Zhang F#, Cao Y#, Liu C#. Deficiency of MFSD6L, an acrosome membrane protein, causes oligoasthenoteratozoospermia in humans and mice. Journal of Genetics and Genomics. 2024, 51(10):1007-1019.

3.Liu C*, Si W*, Tu C*, Tian S*, He X*, Wang S*, Yang X*, Yao C*, Li C, Kherraf Z, Ye M, Zhou Z, Ma Y, Gao Y8, Li Y, Liu Q, Tang S, Wang J, Saiyin H, Zhao L, Yang L, Meng L, Chen B, Tang D, Zhou Y, Wu H, Lv M, Tan C, Lin G, Kong Q, Shi H, Su Z, Li Z, Yao Y, Jin L, Ping Zheng P, Ray PF, Tan Y#, Cao Y# and Zhang F#. Deficiency of primate-specific SSX1 induced asthenoteratozoospermia in infertile men and cynomolgus monkey and tree shrew models. American Journal of Human Genetics. 2023,110(3):516-530.

4.Liu C*, Tu C*, Wang L*, Wu H*, Houston BJ, Mastrorosa FK, Zhang W, Shen Y, Wang J, Tian S, Meng L, Cong J, Yang S, Jiang Y, Tang S, Zeng Y, Lv M, Lin G, Li J, Saiyin H, He X, Jin L, Touré A, Ray PF, Veltman JA, Shi Q#, O'Bryan MK#, Cao Y#, Tan Y#, Zhang F#. Deleterious Variants in X-linked CFAP47 Induce Asthenoteratozoospermia and Primary Male Infertility. American Journal of Human Genetics. 2021,108:309-323. 

5.Liu C*, Miyata H*, Gao Y*, Sha Y*, Tang S*, Xu Z*, Whitfield M, Patrat C, Wu H, Dulioust E, Tian S, Shimada K, Cong J, Noda T, Li H, Morohoshi A, Cazin C, Kherraf ZE, Arnoult C, Jin L, He X, Ray PF#, Cao Y#, Touré A#, Zhang F#, Ikawa M#. Bi-allelic DNAH8 Variants Lead to Multiple Morphological Abnormalities of the Sperm Flagella and Primary Male Infertility. American Journal of Human Genetics. 2020,107:330-341.

6.Liu C*, He X*, Liu W*, Yang S*, Wang L*, Li W, Wu H, Tang S, Ni X, Wang J, Gao Y, Tian S, Zhang L, Cong J, Zhang Z, Tan Q, Zhang J, Li H, Zhong Y, Lv M, Li J, Jin L, Cao Y#, Zhang F#. Bi-allelic Mutations in TTC29 Cause Male Subfertility with Asthenoteratospermia in Humans and Mice. American Journal of Human Genetics. 2019,105:1168-1181.

7.He X*, Liu C*, Yang X*, Lv M*, Ni X*, Li Q*, Cheng H, Liu W, Tian S, Wu H, Gao Y, Yang C, Tan Q, Cong J, Tang D, Zhang J, Song B, Zhong Y, Li H, Zhi W, Mao X, Fu F, Ge L, Shen Q, Zhang M, Saiyin H, Jin L, Xu Y, Zhou P, Wei Z, Zhang F#, Cao Y#. Bi-allelic Loss-of-function Variants in CFAP58 Cause Flagellar Axoneme and Mitochondrial Sheath Defects and Asthenoteratozoospermia in Humans and Mice. American Journal of Human Genetics. 2020,107:514-526. 

8.Liu C#; Zhang F. PIWI-specific insertion module: a newly identified regulatory element essential for longer piRNAs loading and male fertility, Science China Life Sciences, 2023, 66(7): 1708-1710.  

9.Tian S*, Wang Z*, Liu L*, Zhou Y, Lv Y, Tang D, Wang J, Jiang J, Wu H, Tang S, Wang G, Geng H, Tao F, Liu H, He X, Zhang F, Li J, Jin L, Huang T, Liu C# and Cao Y#. A homozygous frameshift mutation in ADAD2 cause male infertility with spermatogenic impairments. Journal of Genetics and Genomics. 2023, 50(4): 284-288. 

10.Liu C*, Shen Y*, Shen Q*, Zhang W*, Wang J*, Tang S, Wu H, Tian S, Cong J, He X, Jin L, Zhang F, Jiang X#, Cao Y#. Novel Mutations in X-Linked, USP26-Induced Asthenoteratozoospermia and Male Infertility. Cells. 2021,10(7):1594. 

11.Liu C*, Lv M*, He X*, Zhu Y*, Amiri-Yekta A, Li W, Wu H, Kherraf ZE, Liu W, Zhang J, Tan Q, Tang S, Zhu YJ, Zhong Y, Li C, Tian S, Zhang Z, Jin L, Ray P, Zhang F#, Cao Y#. Homozygous mutations in SPEF2 induce multiple morphological abnormalities of the sperm flagella and male infertility. Journal of Medical Genetics. 2020, 57(1):31-37.

12.Liu C*, Shen Y*, Tang S*, Wang J*, Zhou Y*, Tian S, Wu H, Cong J, He X, Jin L, Cao Y#, Yang Y#, Zhang F#. Homozygous variants in AKAP3 induce asthenoteratozoospermia and male infertility. Journal of Medical Genetics. 2023, 60(2):137-143.

13.Song B*, Liu C*, Gao Y*, Marley JL*, Li W, Ni X, Liu W, Chen Y, Wang J, Wang C, Zhou P, Wei Z, He X#, Zhang F#, Cao Y#. Novel compound heterozygous variants in dynein axonemal heavy chain 17 cause asthenoteratospermia with sperm flagellar defects. Journal of Genetics and Genomics. 2020, 47: 713-717. 

14.Lv M*, Liu C*, Ma C*, Yu H*, Shao Z*, Gao Y, Liu Y, Wu H, Tang D, Tan Q, Zhang J, Li K, Xu C, Geng H, Zhang J, Li H, Mao X, Ge L, Fu F, Zhong K, Xu Y, Tao F, Zhou P, Wei Z, He X#, Zhang F#, Cao Y#. Homozygous mutation in SLO3 leads to severe asthenoteratozoospermia due to acrosome hypoplasia and mitochondrial sheath malformations. Reproductive Biology and Endocrinology. 2022, 20(1):5.

15.Liu C*, Ajmal M*, Akram Z, Ghafoor T, Farhan M, Shafique S, Wahid S, Bano S, Xiao J, Satti HS, Zhang F#, Khan TN#. Genetic analysis of osteopetrosis in Pakistani families identifies novel and known sequence variants. BMC Medical Genomics. 2021, 14(1):264.

16.Khan A*, Tian S*, Tariq M, Khan S, Safeer M, Ullah N, Akbar N, Javed I, Asif M, Ahmad I, Ullah S, Satti HS, Khan R, Naeem M, Ali M, Rendu J, Fauré J, Dieterich K, Latypova X, Baig SM, Malik NA, Zhang F, Khan TN#, Liu C#. NGS-driven molecular diagnosis of heterogeneous hereditary neurological disorders reveals novel and known variants in disease-causing genes. Molecular Genetics and Genomics. 2022, 297(6):1601-1613.

17.Zhang B*, Khan I*, Liu C*, Ma A, Khan A, Zhang Y, Zhang H, Kakakhel MBS, Zhou J, Zhang W, Li Y, Ali A, Jiang X, Murtaza G, Khan R, Zubair M, Yuan L, Khan M, Wang L, Zhang F, Wang X#, Ma H#, Shi Q#. Novel loss-of-function variants in DNAH17 cause multiple morphological abnormalities of the sperm flagella in humans and mice. Clinical Genetics. 2021,99(1):176-186. 

18.Zhu X*, Liu L*, Tian S*, Zhao G, Zhi E, Chen Q, Zhang F, Zhang A#, Tang S#, Liu C#. Deleterious variant in FAM71D cause male infertility with asthenoteratospermia. Molecular Genetics and Genomics. 2024, 299(1): 35. 

19.Tian S, Faheem M, Satti HS, Xiao J, Zhang F, Khan TN#, Liu C#. A homozygous missense variant in YTHDC2 induces azoospermia in two siblings. Molecular Genetics and Genomics. 2024, 299(1):84.

代表性著作：

无

 

 

 

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