姓名：

徐健

职称：

主任医师

导师类型：

博士生导师

专业：

儿童保健

研究方向：

环境与儿童神经发育

邮箱地址：

sonia0616@sina.com

个人简介

徐健，女，医学博士，儿童保健专业，主任医师，教授，博士生导师，现任职于上海市交通大学医学院附属国际和平妇幼保健院儿童保健科。担任中华医学会公共卫生分会青年委员会委员、常委、副主任委员，上海微量元素学会副秘书长。主要研究方向为环境对儿童发育的影响。有较丰富的儿童保健工作经验，熟练掌握儿保各种疾病的诊治。近二十年来，对微量营养素与儿童生长发育关系进行系列深入研究。近年来以第一负责人承担国家自然科学基金4项，省部级科研项目多项。近年来以第一作者或通讯作者在国内外发表近50篇论文，其中SCI收录30余篇，参编专著5部。

主要科研项目：

1.国家自然科学基金，发育期过度学习负担对神经行为发育影响的流行病学和基础研究，项目负责人

2.国家自然科学基金，BDNF-TrKB-ERK通路在妊娠期铅和精神压力复合暴露影响子代认知发育中的作用机制研究，项目负责人

3.国家自然科学基金，基于铅的骨血转化模式探讨不同年龄段铅中毒儿童治疗的差异性，项目负责人

4.上海市教委，生命早期维生素A营养状态对子代神经发育的影响，项目负责人

代表性论文：

1.Guo X, Xu J*（徐健）, Tian Y, Ouyang F, Yu X, Liu J, Yan C, Zhang J; Shanghai Birth Cohort. Interaction of prenatal maternal selenium and manganese levels on child neurodevelopmental trajectories-the Shanghai birth cohort study. Sci Total Environ. 2024 Mar 10;915:170095. doi: 10.1016/j.scitotenv.2024.170095.

2.Yu T, Xu D, Fan J, Hua H, Guo X, Zhang Y, Jiang S, Huang L, Jiang Y, Wang Y, Yan C, Xu J*（徐健）. Homework, sleep insufficiency and adolescent neurobehavioral problems: Shanghai Adolescent Cohort. J Affect Disord. 2023 Jul 1;332:273-282. doi: 10.1016/j.jad.2023.04.008. Epub 2023 Apr 12. PMID: 37059191.

3.Yu T#, Jiang Y#, Fan J, Guo X, Hua H, Xu D, Wang Y, Yan C, Xu J*（徐健）. Rapid increases in BMI waist to height ratio during adolescence and subsequent neurobehavioral deficits. Obesity (Silver Spring). 2023 Nov;31(11):2822-2833. doi: 10.1002/oby.23881. Epub 2023 Sep 21. PMID: 37735781.

4.Hua H#, Huang L#, Yang B, Jiang S, Zhang Y, Liu J, Yan C, Xu J*（徐健）. The mediating role of gut microbiota in the associations of prenatal maternal combined exposure to lead and stress with neurodevelopmental deficits in young rats. Ecotoxicol Environ Saf. 2023 Apr 15;255:114798. doi: 10.1016/j.ecoenv.2023.114798. Epub 2023 Mar 20. PMID: 36948003.

5.Peng, JY; Gao, ZY; Xu J*（徐健）; Lin, YF; Specht, AJ; Chen, SW; Nie, LH ; Huang, LH ; Yan, CH*. Concurrent Assessment on Blood Lead in Young Children and Toy Lead in Shanghai. EXPOSURE AND HEALTH. 2023.DOI10.1007/s12403-023-00582-9

6.Yu T, Xu J*（徐健）, Jiang Y, Hua H, Zhou Y, Guo X. School educational models and child mental health among K-12 students: a scoping review. Child Adolesc Psychiatry Ment Health. 2022;16(1):32. doi:10.1186/s13034-022-00469-8.

7.Guo X#, Jiang S#, Xu J Xu J*（徐健）, Tian Y, Ouyang F, Yu X, Liu J, Yan C, Zhang J; Shanghai Birth Cohort.  Effects of single and combined exposure to lead and stress during pregnancy on offspring neurodevelopment. Developmental Cognitive Neuroscience. 2022; 56:101124. doi:10.1016/j.dcn.2022.101124.

8.Guo X, Wang H, Xu J(徐健)*, Hua H. Impacts of vitamin A deficiency on biological rhythms: Insights from the literature. Front Nutr. 2022 Nov 18;9:886244.

9.Yu T, Zhou L, Xu J*（徐健）, Kan H, Chen R, Chen S, Hua H, Liu Z, Yan C. Effects of prenatal exposures to air sulfur dioxide/nitrogen dioxide on toddler neurodevelopment and effect modification by ambient temperature. Ecotoxicol Environ Saf. 2021;230:113118. doi:10.1016/j.ecoenv.2021.113118.

10.Guo X, Zhou L, Xu J*（徐健）, Liu Z, Liu J, Yan C. Prenatal Maternal Low Selenium, High Thyrotropin, and Low Birth Weights. Biol Trace Elem Res. 2021;199(1):18-25. doi:10.1007/s12011-020-02124-9

11.Huang L#, Jiang S#, Xu J*（徐健）, Lei X, Zhang J. Associations between prepregnancy body mass index, gestational weight gain and weight catch‐up in small‐for‐gestational‐age children. Maternal & Child Nutrition. Published online July 22, 2021. doi:10.1111/mcn.13235

12.Zhang Y#, Zhou L#, Li S, Liu J, Sun S, Ji X, Yan C, Xu J*（徐健）. Impacts of lead exposure and chelation therapy on bone metabolism during different developmental stages of rats. Ecotoxicol Environ Saf. 2019;183:109441. doi:10.1016/j.ecoenv.2019.109441.

13.Xu J*（徐健）, Hu H*, Wright R, Schnaas L, Bellinger DC, Park SK, Wright RO, Téllez-Rojo MM. Prenatal lead exposure modifies the association of maternal self-esteem with child adaptive ability. Int J Hyg Environ Health. 2019;222(1):68-75. doi:10.1016/j.ijheh.2018.08.005

14.Lin Y#, Huang L#, Xu J*（徐健）, Specht AJ, Yan C, Geng H, Shen X, Nie LH*, Hu H. Blood lead, bone lead and child attention-deficit-hyperactivity-disorder-like behavior. Sci Total Environ. 2019;659:161-167. doi:10.1016/j.scitotenv.2018.12.219

15.Specht AJ, Lin Y, Xu J（徐健）, Weisskopf M, Nie LH. Bone lead levels in an environmentally exposed elderly population in shanghai, China. Sci Total Environ. 2018;626:96-98. doi:10.1016/j.scitotenv.2018.01.091