赵欣之
基本信息 | ||
| 姓名： | 赵欣之 |
职称： | 研究员 | |
导师类型： | 硕士生导师 | |
专业： | 医学遗传学 | |
研究方向： | 复杂疾病的遗传和表观遗传机制 | |
邮箱地址： | xzzhaoipmch@163.com | |
个人简介 | ||
2006年在上海交通大学获生物化学与分子生物学博士学位。主要从事妊娠重大疾病和复杂出生缺陷研究，通过高通量遗传检测技术鉴定疾病相关的遗传和表观遗传变异，探索母胎相互作用的拮抗性适应分子机制。作为课题负责人承担国家973、重点研发计划2项，国家自然科学基金项目2项，省部级项目3项。迄今在《American Journal of Human Genetics》、《Molecular Psychiatry》等SCI刊物上发表论文60余篇，被引用900余次；其中第一和通讯作者21篇，被引用300余次；作为第一发明人申请专利1项。2009年入选上海市青年科技启明星（A类）。
主要科研项目 1. ART 对配子表观基因组影响及筛选策略，国家重点研发计划课题，2018YFC1005001，课题负责人 2. 子痫前期胎盘DNA广泛性低甲基化的发生机制研究及分子分型探索，国家自然科学基金面上项目，81871180项目负责人 3. 染色质修饰与精神分裂症,973项目课题，2009CB825606，课题负责人 4. 拷贝数变异与精神分裂症的关联研究，国家自然科学基金青年项目，30800616，项目负责人 5. 常见X染色体疾病的分子遗传检测新方法研究 上海市科委医学引导项目 16411968100, 项目负责人 6. 罕见遗传变异中的常见功能多态性与精神分裂症 上海市科学技术启明星项目（A类），09QA1400500，项目负责人
代表性论文（#第一作者，*通讯作者） 1. Zhang,Qiang #;Guo,Xiaohong#; Tian, Tian;Wang,Teng; Li,Qiaoli; Wang, Lei; Liu, Yun; Xing, Qinghe; He, Lin; *Zhao, Xinzhi Detection of Turner syndrome using X-chromosome inactivation specific differentially methylated CpG sites: A pilot study. Clin Chim Acta. 468:174-179. 2017. 2. Zhou, Xinyao #; Li,Qiaoli #; Xu, JiaweiZhang; Xiaojing, Zhang, Juan;Xiang, Yuqian; Fang, Chuantao;Wang, Teng; Xia, Shihui; Zhang, Qiang; Xing, Qinghe;He, Lin;*Wang Lei; Xu*Mingqing, *Zhao Xinzhi. The aberrantly expressed miR-193b-3p contributes to preeclampsia through regulating transforming growth factor-beta signaling，Scientific Reports，6:19910. 2016 3. Li,Zhiqiang#; Xiang, Yuqian#; Chen, Jianhua; Li, Qiaoli; Shen, Jiawei, Liu,Yun, Li, Wenjin, Xing, Qinghe;Wang,Qingzhong; Wang, Lei; Feng, Guoyin; He, Lin;*Zhao, Xinzhi;*Yongyong Shi. Loci with genome-wide associations with schizophrenia in the Han Chinese population British Journal of Psychiatry207 (6): 490-4. 2015 4. Xu,Jiawei#; He, Guang#; Zhu Jingde; Zhou Xinyao; David St Clair;Wang,Teng; Xiang, Yuqian; Zhao Qingzhu;Xing,Qinghe; Liu, Yun; Wang, Lei; Li, Qiaoli; *He, Lin;*Zhao,Xinzhi. 2014 Prenatal nutritional deficiency reprogrammed postnatal gene expression in mammal brains: implications for schizophrenia.International Journal of Neuropsychopharmacology,pii: pyu054. 2014 5. Xiang, Yuqian #; Zhang, Junyu#; Li, Qiaoli;Zhou, Xinyao; Wang, Teng; Xia, Shihui; Xing, Qinghe; Wang, Lei; He, Lin; *Zhao,Xinzhi.2014 DNA methylome profiling of maternal peripheral blood and placenta reveal potential fetal DNA markers for noninvasive prenatal testing. Molecular Human Reproduction, 20(9):875-84 2014 6. Gong, Yunguo#, Wu, Chaoneng#, Xu, Jiawei#, Feng, Guoying, Xing, Qinghe, Fu, Wei, Li, Chong, *He, Lin, *Zhao, Xinzhi. 2013 Polymorphisms in microRNA target sites influence susceptibility to schizophrenia by altering the binding of miRNAs to their targets. European Neuropsychopharmacology, 23(10):1182-9, 2013. 7. Xiang, Yuqian; Zhang, Xiaojing; Li, Qiaoli; Xu, Jiawei; Zhou, Xinyao; Wang, Teng; Xing, Qinghe; Liu, Yun; Wang, Lei; He, Lin; *Zhao, Xinzhi, 2013, Promoter hypomethylation of TIMP3 is associated with pre-eclampsia in a Chinese population, Molecular Human Reproduction, 19(3), pp 153-159 2013 8. Zhao, Xinzhi#; Tang, Ruqi #; Gao, Bo; Shi, Yongyong; Zhou, Jian; Guo, Shengzhen; Zhang, Jing; Wang, Yabing; Tang, Wei; Meng, Junwei; Li, Sheng; Wang, Hongsheng; Ma, Gang; Lin, Chuwen; Xiao, Yue; Feng, Guoyin; Lin, Zhiguang; Zhu, Shaomin; Xing, Yangling; Sang, Hong; St. Clair, David; He, Lin, Functional variants in the promoter region of chitinase 3-like 1 (CHI3L1) and susceptibility to schizophrenia, American Journal of Human Genetics, 80(1) 2007 9. Zhao, Xinzhi #; Li, Huafang #; Shi, Yongyong; Tang, Ruqi; Chen, Wuyan; Liu, Jixia; Feng, Guoyin; Shi, Jianguo; Yan, Lijuan; Liu, Huijun, *He, Lin. 2006, Significant association between the genetic variations in the 5 '; end of the N-methyl-D-aspartate receptor subunit gene GRIN1 and schizophrenia, Biological Psychiatry, 59(8), pp 747-753 2006 10. Tang, Ruqi #; Zhao, Xinzhi #; Shi, YY #; Tang, W; Gu, NF; Feng, GY; Xing, YL; Zhu, SM; Sang, H; Liang, PJ; *He, L, 2006, Family-based association study of Epsin 4 and schizophrenia, Molecular Psychiatry, 11(4), pp 395-399 2006 | ||
