姓名：

赵欣之

职称：

研究员

导师类型：

硕导

专业：

妇产科学

研究方向：

妊娠重大疾病

邮箱地址：

xzzhaoipmch@sjtu.edu.cn

个人简介

赵欣之，理学博士、上海交通大学医学院附属国际和平妇幼保健院中心实验室研究员。主要从事妊娠重大疾病和复杂出生缺陷研究作为课题负责人承担国家973、重点研发计划2项，国家自然科学基金项目2项，省部级项目3项。迄今在《American Journal of Human Genetics》、《Molecular Psychiatry》等SCI刊物上发表论文60余篇；作为第一发明人申请专利1项。2009年入选上海市青年科技启明星（A类）。

主要研究方向：

1. 正常和妊娠重大疾病中胎盘的表观遗传调控；

2. 妊重大疾病中母胎相互作用的拮抗性适应分子机制；

3. 妊重大疾病的无创预测方法。

主要科研项目：

1.国家科技部重点研发项目/课题1，2018YFC1005001, ART 对配子表观基因组影响及筛选策略，课题负责人

2.国家科技部973项目/课题6，2009CB825606，染色质修饰与精神分裂症，课题负责人

3.国家自然科学基金面上项目, 81871180, 子痫前期胎盘DNA广泛性低甲基化的发生机制研究及分子分型探索, 项目负责人

4.国家自然科学基金青年项目，30800616，拷贝数变异与精神分裂症的关联研究，项目负责人

5.上海市科委，自然科学基金面上项目，子痫前期胎盘基因组增强子表观遗传调控研究及应用探索，22ZR1467800，项目负责人

6.上海市科委，医学引导项目，1641196810，常见X染色体疾病的分子遗传检测新方法研究，项目负责人

7.上海市科委，青年科技启明星（A类），09QA1400500，罕见遗传变异中的常见功能多态性与精神分裂症，项目负责人

代表性论文：

1.Xiaoguo Zheng#, Weibin Wu#, Qian Zhou, Yahan Lian, Yuqian Xiang*, Xinzhi Zhao*; Targeted bisulfite resequencing of differentially methylated cytosines in pre-eclampsia reveals a skewed dynamic balance in the DNA methylation of enhancers, Clinical Science, 2023, 137(3): 265-279

2.Xiaoguo Zheng,Yahan L,Jing Z, et al. Placental ischemia disrupts DNA methylation patterns in distal regulatory regions in rats. Life sciences 2023,321

3.Xiaoguo Zheng#, Xinzhi Zhao*. A hypothetical model of skewed DNA methylation balance in the enhancer regions containing differentially methylated cytosines associated with nonmalignant complex diseases. Medical Hypotheses, 2022; 168

4.Jiaying Chen# , Xinzhi Zhao# , Li Cui , Guang He , Xinhui wang , Fudi wang , Shiwei Duan , Lin He , Qiang Li , Xiaodan Yu , Fuquan Zhang, Mingqing Xu*. Genetic regulatory subnetworks and key regulating genes in rat hippocampus perturbed by prenatal malnutrition: implications for major brain disorders. Aging. 2020;12(9):8434-8458.

5.Fei Xu #, Xin Li #, Weibo Niu, Gaini Ma, Qianqian Sun, Yan Bi, Zhenming Guo , Decheng Ren, Jiaxin Hu, Fan Yuan, Ruixue Yuan, Lei Shi, Xingwang Li, Tao Yu, Fengping Yang, Lin He, Xinzhi Zhao*, Guang He*. Metabolomic profiling on rat brain of prenatal malnutrition: implicated for oxidative stress and schizophrenia.Metab Brain Dis. 2019;34(6):1607-1613. 2019/10

6.Teng Wang #, Yuqian Xiang#, Xinyao Zhou, Xiaoguo Zheng, Huijuan Zhang, Xiaojing Zhang, Junyu Zhang, Lin He, Xinzhi Zhao* Epigenome-wide association data implicate fetal/maternal adaptations contributing to clinical outcomes in preeclampsia. Epigenomics. 2019 ;11(9):1003-1019.

7.Xu Jiawei#, Wang Teng#, Su Zhiyang#, Zhou Xinyao, Xiang Yuqian, He Lin, Li Cangdong, *Yang Zhaoyang, *Zhao Xinzhi，2018 Opioid Exposure is Associated with Aberrant DNA Methylation of OPRM1 Promoter Region in a Chinese Han Population. Biochem Genet. 56(5):451-458 2018/10

8.Zhang,Qiang #;Guo,Xiaohong#; Tian, Tian;Wang,Teng; Li,Qiaoli; Wang, Lei; Liu, Yun; Xing, Qinghe; He, Lin; *Zhao, Xinzhi Detection of Turner syndrome using X-chromosome inactivation specific differentially methylated CpG sites: A pilot study. Clin Chim Acta. 468:174-179. 2017/5.

9.Gu, Ye#; Zhou, Xinyao#; Hu, Fan; Yu, Yong; Xie, Tao; Huang, Yuying; Zhao, Xinzhi*;Zhang, Xiaobiao* Differential DNA methylome profiling of nonfunctioning pituitary adenomas suggesting tumour invasion is correlated with cell adhesion. J Neurooncol. 129(1):23-31. 2016/8 1

10.Zhou, Xinyao #; Li,Qiaoli #; Xu, Jiawei, Zhang; Xiaojing, Zhang, Xiang, Yuqian; Fang, Chuantao;Wang, Teng; Xia, Shihui; Zhang, Qiang; Xing, Qinghe;He, Lin;*Wang Lei; Xu*Mingqing, *Zhao Xinzhi. The aberrantly expressed miR-193b-3p contributes to preeclampsia through regulating transforming growth factor-beta signaling，Scientific Reports，6:19910. 2016/1

11.Li,Zhiqiang#; Xiang, Yuqian#; Chen, Jianhua; Li, Qiaoli; Shen, Jiawei, Liu,Yun, Li, Wenjin, Xing, Qinghe;Wang,Qingzhong; Wang, Lei; Feng, Guoyin; He, Lin;*Zhao, Xinzhi;*Yongyong Shi. Loci with genome-wide associations with schizophrenia in the Han Chinese population British Journal of Psychiatry207 (6): 490-4. 2015/12

代表性著作：

1.表观遗传学 978-7-03-073789-2，专著，2023/3，科学出版社，参编

2.今日遗传咨询978-7-11-726102-9，专著，2019/01，人民卫生出版社，参编