基本信息

姓名:

赵欣之

职称:

研究员

导师类型:

硕士生导师

专业:

医学遗传学

研究方向:

复杂疾病的遗传和表观遗传机制

邮箱地址:

xzzhaoipmch@163.com

个人简介

 

2006年在上海交通大学获生物化学与分子生物学博士学位。主要从事妊娠重大疾病和复杂出生缺陷研究,通过高通量遗传检测技术鉴定疾病相关的遗传和表观遗传变异,探索母胎相互作用的拮抗性适应分子机制。作为课题负责人承担国家973、重点研发计划2项,国家自然科学基金项目2项,省部级项目3项。迄今在《American Journal of Human Genetics》、《Molecular Psychiatry》等SCI刊物上发表论文60余篇,被引用900余次;其中第一和通讯作者21篇,被引用300余次;作为第一发明人申请专利1项。2009年入选上海市青年科技启明星(A类)。

 

主要科研项目

1.    ART 对配子表观基因组影响及筛选策略,国家重点研发计划课题,2018YFC1005001,课题负责人

2.    子痫前期胎盘DNA广泛性低甲基化的发生机制研究及分子分型探索,国家自然科学基金面上项目,81871180项目负责人

3.    染色质修饰与精神分裂症,973项目课题,2009CB825606,课题负责人

4.    拷贝数变异与精神分裂症的关联研究,国家自然科学基金青年项目,30800616,项目负责人

5.    常见X染色体疾病的分子遗传检测新方法研究 上海市科委医学引导项目 16411968100, 项目负责人

6.    罕见遗传变异中的常见功能多态性与精神分裂症 上海市科学技术启明星项目(A类),09QA1400500,项目负责人

 

代表性论文(#第一作者,*通讯作者)

1.    Zhang,Qiang #;Guo,Xiaohong#; Tian, Tian;Wang,Teng; Li,Qiaoli; Wang, Lei; Liu, Yun; Xing, Qinghe; He, Lin; *Zhao, Xinzhi Detection of Turner syndrome using X-chromosome inactivation specific differentially methylated CpG sites: A pilot study. Clin Chim Acta. 468:174-179. 2017.

2.    Zhou, Xinyao #; Li,Qiaoli #; Xu, JiaweiZhang; Xiaojing, Zhang, Juan;Xiang, Yuqian; Fang, Chuantao;Wang, Teng; Xia, Shihui; Zhang, Qiang; Xing, Qinghe;He, Lin;*Wang Lei; Xu*Mingqing, *Zhao Xinzhi. The aberrantly expressed miR-193b-3p contributes to preeclampsia through regulating transforming growth factor-beta signaling,Scientific Reports,6:19910. 2016

3.    Li,Zhiqiang#; Xiang, Yuqian#; Chen, Jianhua; Li, Qiaoli; Shen, Jiawei, Liu,Yun, Li, Wenjin, Xing, Qinghe;Wang,Qingzhong; Wang, Lei; Feng, Guoyin; He, Lin;*Zhao, Xinzhi;*Yongyong Shi. Loci with genome-wide associations with schizophrenia in the Han Chinese population British Journal of Psychiatry207 (6): 490-4. 2015

4.    Xu,Jiawei#; He, Guang#; Zhu Jingde; Zhou Xinyao; David St Clair;Wang,Teng; Xiang, Yuqian; Zhao Qingzhu;Xing,Qinghe; Liu, Yun; Wang, Lei; Li, Qiaoli; *He, Lin;*Zhao,Xinzhi. 2014 Prenatal nutritional deficiency reprogrammed postnatal gene expression in mammal brains: implications for schizophrenia.International Journal of Neuropsychopharmacology,pii: pyu054. 2014

5.    Xiang, Yuqian #; Zhang, Junyu#; Li, Qiaoli;Zhou, Xinyao; Wang, Teng; Xia, Shihui; Xing, Qinghe; Wang, Lei; He, Lin; *Zhao,Xinzhi.2014 DNA methylome profiling of maternal peripheral blood and placenta reveal potential fetal DNA markers for noninvasive prenatal testing. Molecular Human Reproduction, 20(9):875-84 2014

6.    Gong, Yunguo#, Wu, Chaoneng#, Xu, Jiawei#, Feng, Guoying, Xing, Qinghe, Fu, Wei, Li, Chong, *He, Lin, *Zhao, Xinzhi. 2013 Polymorphisms in microRNA target sites influence susceptibility to schizophrenia by altering the binding of miRNAs to their targets. European Neuropsychopharmacology, 23(10):1182-9, 2013.

7.    Xiang, Yuqian;  Zhang, Xiaojing;  Li, Qiaoli;  Xu, Jiawei;  Zhou, Xinyao;  Wang, Teng;  Xing, Qinghe;  Liu, Yun;  Wang, Lei;  He, Lin;  *Zhao, Xinzhi, 2013, Promoter hypomethylation of TIMP3 is associated with pre-eclampsia in a Chinese population, Molecular Human Reproduction, 19(3), pp 153-159 2013

8.    Zhao, Xinzhi#; Tang, Ruqi #; Gao, Bo; Shi, Yongyong; Zhou, Jian; Guo, Shengzhen; Zhang, Jing; Wang, Yabing; Tang, Wei;  Meng, Junwei; Li, Sheng;  Wang, Hongsheng; Ma, Gang; Lin, Chuwen; Xiao, Yue; Feng, Guoyin;  Lin, Zhiguang; Zhu, Shaomin; Xing, Yangling;  Sang, Hong; St. Clair, David; He, Lin, Functional variants in the promoter region of chitinase 3-like 1 (CHI3L1) and susceptibility to schizophrenia, American Journal of Human Genetics, 80(1) 2007

9.    Zhao, Xinzhi #; Li, Huafang #; Shi, Yongyong; Tang, Ruqi; Chen, Wuyan; Liu, Jixia; Feng, Guoyin; Shi, Jianguo; Yan, Lijuan; Liu, Huijun, *He, Lin. 2006, Significant association between the genetic variations in the 5 '; end of the N-methyl-D-aspartate receptor subunit gene GRIN1 and schizophrenia, Biological Psychiatry, 59(8), pp 747-753 2006

10.   Tang, Ruqi #; Zhao, Xinzhi #; Shi, YY #; Tang, W; Gu, NF; Feng, GY; Xing, YL; Zhu, SM; Sang, H; Liang, PJ; *He, L, 2006, Family-based association study of Epsin 4 and schizophrenia, Molecular Psychiatry, 11(4), pp 395-399 2006

 

 

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