基本信息

姓名：

林羿

职称：

研究员

导师类型：

博士生导师

专业：

妇产科学

研究方向：

生殖免疫

邮箱地址：

yilinonline@126.com

个人简介

上海交通大学特聘教授。上海交通大学医学院附属国际和平妇幼保健院研究员、博导。国家杰出青年基金获得者。上海领军人才。上海市优秀学术带头人。国家重点研发计划项目首席科学家。在《Journal of Pathology》和《Journal of Immunology》等期刊发表SCI论文50余篇，共被Web of Science核心合集引用800余次，包括被发表在《Nature》的两篇论文引用（截至2018年底）。获得国家科技进步二等奖、国家计生委优秀科技成果一等奖（均为第二完成人）。主要科研贡献：在妊娠相关疾病机理方面的科学发现。

主要科研项目

1.    Toll-like receptor involved cell signaling and the mechanism of pregnancy tolerance, 2007-2009, funded by National Natural Science Foundation of China (30672231);

2.    The origin of regulatory T cells and their role in feto-maternal tolerance, 2008-2011, partially funded by the Major Project of National Natural Science Foundation of China (30730087);

3.    Regulatory NK cells and the mechanisms of pregnancy tolerance, 2009-2011, Funded by National Natural Science Foundation of China (30872761).

4.    Obstetrics and Gynecology, 2011-2014, the National Funds for Distinguished Young Scientists, China (81125004).

代表性论文（^#第一作者，*通讯作者）

1.    Tian FJ^#, He XY, Wang J, Li X, Ma XL, Wu F, Zhang J, Liu XR, Qin XL, Zhang Y, Zeng WH*, Lin Y*. Elevated tristetraprolin impairs trophoblast invasion in women with recurrent miscarriage by destabilization of HOTAIR. Molecular Therapy: Nucleic Acids 2018; 12:600-609. Doi:10.1016/j.omtn.2018.07.001.

2.    Zhang J^#, Mo HQ, Tian FJ, Zeng WH, Liu XR, Ma XL, Li X, Qin S, Fan CF, Lin Y*. EIF5A1 promotes trophoblast migration and invasion via ARAF-mediated activation of the integrin/ERK signaling pathway. Cell Death and Disease 2018; 9(9): 926. Doi:10.1038/s41419-018-0971-5

3.    Zhang J^#, Liu W^#, Shen F, Ma X, Liu X, Tian F, Zeng W, Xi X*, Lin Y*. The activation of microRNA-520h–associated TGF-β1/c-Myb/Smad7 axis promotes epithelial ovarian cancer progression. Cell Death and Disease 2018; 9(9): 884. DOI: 10.1038/s41419-018-0946-6

4.    Zeng W^#, Liu X^#, Liu Z^#, Zheng Y, Yu T, Fu S, Li X, Zhang J, Zhang S, Ma X, Liu X-R, Qin X, Khanniche A, Zhang Y*, Tian F*, Lin Y*. Deep surveying of the transcriptional and alternative splicing signatures for decidual CD8⁺ T cells at the first trimester of human healthy pregnancy. Frontiers in Immunology 2018; 9:937. doi: 10.3389/fimmu.2018.00937

5.    Zeng W^#, Liu Z^#, Liu X, Zhang S, Khanniche A, Zheng Y, Ma X, Yu T, Tian F, Liu X-R, Fan J, Lin Y*. Distinct transcriptional and alternative splicing signatures of decidual CD4⁺ T cells in early human pregnancy. Frontiers in Immunology 2017; 8:682. doi:10.3389/fimmu.2017.00682

6.    Zhang Y^#, Jin F^#, Li X-C, Shen F-J, Ma X-L, Wu F, Zhang S-M, Zeng W-H, Liu X-R, Fan J-X, Lin Y, Tian F-J*. The YY1-HOTAIR-MMP2 signaling axis controls trophoblast invasion at the maternal-fetal interface. Molecular Therapy 2017; 25(10): 2394-2403.

7.    Zeng W^#, Liu Z, Zhang S, Ren J, Ma X, Qin C, Tian F, Zhang Y*, Lin Y*. Characterization of T follicular helper cells in allogeneic normal pregnancy and PDL1 blockage induced abortion. Scientific Reports 2016; 6:36560.  DOI: 10.1038/srep36560 (IF: 4.259)

8.    Tian FJ^#, Cheng YX^#, Li XC, Wang F, Qin CM, Ma XL, Yang J*, Lin Y*. The YY1/MMP2 axis promotes trophoblast invasion at the maternal-fetal interface. J Pathol 2016; 239:36-47. (IF: 6.894)

9.    Tian FJ^#, Qin CM^#, Li XC, Wu F, Liu XR, Xu WM*, Lin Y*. Decreased stathmin-1 expression inhibits trophoblast proliferation and invasion and is associated with recurrent miscarriage. Am J Pathol 2015; 185(10):2709-2721. (IF: 4.591)

10.   Wen S-Y^#, Lin Y^#, Yu Y-Q, Cao S-J, Zhang R, Yang X-M, Li J, Zhang Y-L, Wang Y-H, Ma M-Z, Sun W-W, Lou X-L, Wang J-H, Teng Y-C*, Zhang Z-G*. miR-506 acts as a tumor suppressor by directly targeting the hedgehog pathway transcription factor Gli3 in human cervical cancer. Oncogene 2015; 34(6): 717-725. (IF: 7.932)

获奖

1.    免疫型复发性流产发病机制、诊断和治疗研究。“十一五”人口和计生优秀科技成果一等奖。中华人民共和国人口和计划生育委员会。第二完成人。2011年。

2.    免疫型复发性流产的发病机制及诊治。国家科技进步二等奖。第二完成人。2008年。